Yes, but I heard that E85 vehicles run a higher fuel consumption when burning Ethanol. Whither true or not I don’t know.

I know the Ford Expedition has been modified to run E85 Ethanol for the 2009 model year. It bears a "Flex Fuel" emblem on the liftgate. Supposedly it can run strait Gas/Petrol or any mix of both Gas or Ethanol or just strait Ethanol.

Several GM cars are E85 capable (though I can’t remember which ones)